Biological Activity
Group I mGlu receptor antagonist (Kb values are 30 and 61 μM at mGlu1a and mGlu5a receptors respectively). Enantiomer of hexylHIBO (Cat. No. 1749).
Technical Data
| M. Wt | 256.3 |
| Formula | C12H20N2O4 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 334887-48-8 |
| PubChem ID | 6604908 |
| InChI Key | OKJBLHIYOWSQDJ-VIFPVBQESA-N |
| Smiles | OC1=NOC(C[C@@H](C(O)=O)N)=C1CCCCCC |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1eq. NaOH | 5.13 | 20 |
Preparing Stock Solutions
The following data is based on the product molecular weight 256.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.9 mL | 19.51 mL | 39.02 mL |
| 5 mM | 0.78 mL | 3.9 mL | 7.8 mL |
| 10 mM | 0.39 mL | 1.95 mL | 3.9 mL |
| 50 mM | 0.08 mL | 0.39 mL | 0.78 mL |
Molarity Calculator
Reconstitution Calculator
Dilution Calculator
Product Datasheets
References
References are publications that support the products' biological activity.
Madsen et al (2001) Synthesis and pharmacology of 3-isoxazolol amino acids as selective antagonists at group I metabotropic glutamic acid receptors J.Med.Chem. 44 1051 PMID: 11297452
Keywords: (S)-HexylHIBO, supplier, Group, I, mGlur, antagonists, Receptors, mGlu1, mGluR1, mGlu5, mGluR5, Glutamate, Metabotropic, (S)-Hexylhomoibotenic, acid, Glutamate, (Metabotropic), Group, I, Receptors, Glutamate, (Metabotropic), Group, I, Receptors, Tocris Bioscience
