Biological Activity
Endogenous agonist at histamine receptors (H1-4). Released from mast cells and basophils and exhibits inflammatory, vasodilatory and bronchoconstrictory activity. Stimulates gastric acid secretion and acts as a neurotransmitter in vivo.
Compound Libraries
Histamine dihydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 184.07 |
| Formula | C5H9N3.2HCl |
| Storage | Desiccate at RT |
| CAS Number | 56-92-8 |
| PubChem ID | 5818 |
| InChI Key | PPZMYIBUHIPZOS-UHFFFAOYSA-N |
| Smiles | NCCC1=CNC=N1.Cl.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 18.41 | 100 | |
| water | 18.41 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 184.07. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 5.43 mL | 27.16 mL | 54.33 mL |
| 5 mM | 1.09 mL | 5.43 mL | 10.87 mL |
| 10 mM | 0.54 mL | 2.72 mL | 5.43 mL |
| 50 mM | 0.11 mL | 0.54 mL | 1.09 mL |
Molarity Calculator
Reconstitution Calculator
Dilution Calculator
Product Datasheets
References
References are publications that support the products' biological activity.
Hill et al (1997) International union of pharmacology. XIII. Classification of histamine receptors. Pharmacol.Rev. 49 253 PMID: 9311023
Thurmond et al (2008) The role of histamine H1 and H4 receptors in allergic inflammation: the search for new antihistamines. Nat.Rev.Drug Discov. 7 41 PMID: 18172439
Maintz and Novak (2007) Histamine and histamine intolerance. Am.J.Clin.Nutr. 85 1185 PMID: 17490952
Keywords: Histamine dihydrochloride, supplier, Endogenous, histamine, receptor, agonists, H4, Receptors, Histamine, H1, H2, H3, histaminergic, Histamine, H1, Receptors, Histamine, H2, Receptors, Histamine, H3, Receptors, Histamine, H4, Receptors, Histamine, H1, Receptors, Tocris Bioscience
