Biological Activity
Potent NMDA receptor agonist; subtype-selective.
Technical Data
| M. Wt | 181.15 |
| Formula | C8H7NO4 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 490-75-5 |
| PubChem ID | 3080554 |
| InChI Key | HQPMJFFEXJELOQ-UHFFFAOYSA-N |
| Smiles | OC(=O)CC1=CC=CN=C1C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 100 mM in 1eq. NaOH |
Preparing Stock Solutions
The following data is based on the product molecular weight 181.15. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 5.52 mL | 27.6 mL | 55.2 mL |
| 5 mM | 1.1 mL | 5.52 mL | 11.04 mL |
| 10 mM | 0.55 mL | 2.76 mL | 5.52 mL |
| 50 mM | 0.11 mL | 0.55 mL | 1.1 mL |
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References
References are publications that support the products' biological activity.
Olverman et al (1988) Structure/activity relations of NMDA receptor ligands as studied by their inhibition of [3H]-D-2-amino-5-phosphonopentanoic acid binding in rat brain membranes. Neuroscience 26 17 PMID: 2901691
Prado de Carvalho et al (1996) The endogenous agonist quinolinic acid and the non-endogenous homoquinolinic acid discriminate between NMDAR2 receptors subunits. Neurochem.Int. 28 445 PMID: 8740453
Stone (1984) Excitant activity of methyl derivatives of quinolinic acid on rat cortical neurones. Br.J.Pharmacol. 81 175 PMID: 6546701
Keywords: Homoquinolinic acid, supplier, Selective, potent, NMDA, agonists, Glutamate, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, NMDA, Receptors, NMDA, Receptors, Tocris Bioscience
