Biological Activity
Anti-inflammatory, antioxidant, antitumor and antiangiogenic agent. Blocks NF-κB activation by a variety of stimuli, including TNF and okadaic acid. Shown to scavenge superoxide and peroxyl radicals. Also inhibits a variety of inflammatory responses. Reverses cardiac hypertrophy in mice via SIRT3 activation.
Technical Data
| M. Wt | 266.33 |
| Formula | C18H18O2 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 35354-74-6 |
| PubChem ID | 72303 |
| InChI Key | FVYXIJYOAGAUQK-UHFFFAOYSA-N |
| Smiles | OC1=C(C2=CC(CC=C)=C(O)C=C2)C=C(CC=C)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 26.63 | 100 | |
| ethanol | 26.63 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 266.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.75 mL | 18.77 mL | 37.55 mL |
| 5 mM | 0.75 mL | 3.75 mL | 7.51 mL |
| 10 mM | 0.38 mL | 1.88 mL | 3.75 mL |
| 50 mM | 0.08 mL | 0.38 mL | 0.75 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Kim and Cho (2008) Anti-inflammatory effect of honokiol is mediated by PI3K/Akt pathway suppression. Acta Pharmacol.Sinica 29 113 PMID: 18158873
Dikalov et al (2008) Honokiol is a potent scavenger of superoxide and peroxyl radicals. Biochem.Pharmacol. 76 589 PMID: 18640101
Ahn et al (2006) Honokiol potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through modulation of nuclear factor-κB activation pathway. Mol.Cancer Res. 4 621 PMID: 16966432
Bai et al (2003) Honokiol, a small molecular weight natural product, inhibits angiogenesis in vitro and tumor growth in vivo. J.Biol.Chem. 278 35501 PMID: 12816951
Pillai et al (2015) Nat.Commun. 6 6656 PMID: 25871545
Keywords: Honokiol, supplier, anti-inflammatories, antioxidants, antitumor, antiangiogenics, nf-kb, nf-kappa, b, nf-κb, inhibitors, inhibits, NF-kB/IkB, Antioxidants, Sir2-like, Family, Deacetylases, NF-kB/IkB, Tocris Bioscience
