Biological Activity
D3 dopamine receptor agonist (Ki values are ~ 1, 10, 650 and ~ 5000 nM for D3, D2, D4 and D1 receptors respectively). (R)-(+)-8-Hydroxy-DPAT hydrobromide (Cat. No. 1080) and 8-Hydroxy-DPAT hydrobromide (Cat. No 0529) also available.
Compound Libraries
7-Hydroxy-DPAT hydrobromide is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 328.28 |
| Formula | C16H25NO.HBr |
| Storage | Desiccate at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 76135-30-3 |
| PubChem ID | 11957566 |
| InChI Key | ODNDMTWHRYECKX-UHFFFAOYSA-N |
| Smiles | Br.CCCN(CCC)C1CCC2=CC=C(O)C=C2C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 32.83 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 328.28. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.05 mL | 15.23 mL | 30.46 mL |
| 5 mM | 0.61 mL | 3.05 mL | 6.09 mL |
| 10 mM | 0.3 mL | 1.52 mL | 3.05 mL |
| 50 mM | 0.06 mL | 0.3 mL | 0.61 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Daly and Waddington (1993) Behavioural effects of the D3 dopamine receptor agonist 7-OH-DPAT in relation to other D2-like agonists. Neuropharmacology 32 509 PMID: 8321432
Levesque (1996) Aminotetralin drugs and D3 receptor fuctions. Biochem.Pharmacol. 52 511 PMID: 8759022
Levesque et al (1992) Identification, characterization, and localization of the dopamine D3 receptor in rat brain using [3H]-7-hydroxy-N,N-di-n-propyl-2-aminotetralin. Proc.Natl.Acad.Sci.U.S.A. 89 8155 PMID: 1518841
Seeman and Van Tol (1994) Dopamine receptor pharmacology. TiPS 15 264 PMID: 7940991
Keywords: 7-Hydroxy-DPAT hydrobromide, supplier, Dopamine, agonists, D3, Receptors, dopaminergic, D3, Receptors, D3, Receptors, Tocris Bioscience
