Biological Activity
Selective catecholaminergic neurotoxin. Depletes brain catecholamine levels via uptake and accumulation by a transport mechanism specific to these neurons. Causes almost complete destruction of nigral dopaminergic neurons and their striatal terminals when injected into the substantia nigra of rats, producing an animal model of Parkinson's disease.
Technical Data
| M. Wt | 250.09 |
| Formula | C8H11NO3.HBr |
| Storage | Desiccate at -20°C |
| CAS Number | 636-00-0 |
| PubChem ID | 176170 |
| InChI Key | MLACDGUOKDOLGC-UHFFFAOYSA-N |
| Smiles | NCCC1=CC(O)=C(O)C=C1O.Br |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 20.56 | 100 | |
| water | 20.56 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 250.09. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4 mL | 19.99 mL | 39.99 mL |
| 5 mM | 0.8 mL | 4 mL | 8 mL |
| 10 mM | 0.4 mL | 2 mL | 4 mL |
| 50 mM | 0.08 mL | 0.4 mL | 0.8 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Breese and Traylor (1970) Effect of 6-hydroxydopamine on brain norepinephrine and dopamine: evidence for selective degeneration of catecholamine neurons. J.Pharmacol.Exp.Ther. 174 413 PMID: 5456173
Soto-Otero et al (2000) Autoxidation and neurotoxicity of 6-hydroxydopamine in the presence of some antioxidants: potential implication in relation to the pathogenesis of Parkinson's disease. J.Neurochem. 74 1605 PMID: 10737618
Fujita et al (2006) Cell-permeable cAMP analog suppresses 6-hydroxydopamine-induced apoptosis in PC12 cells through the activation of the Akt pathway. Brain Res. 1113 10 PMID: 16945353
Keywords: 6-Hydroxydopamine hydrobromide, supplier, Selective, catecholaminergic, neurotoxin, Dopamine, Receptors, adrenoceptors, adrenergic, dopaminergic, neurotoxins, parkinson's, parkinsons, 6-OHDA, Dopaminergic-Related, Adrenergic, Related, Compounds, Dopaminergic-Related, Tocris Bioscience
