Biological Activity
Agonist at group I metabotropic glutamate receptors (mGlu1) having no effect at mGlu2 or mGlu4. (RS)-3-Hydroxyphenylglycine (Cat. No. 0324) also available.
Technical Data
| M. Wt | 167.16 |
| Formula | C8H9NO3 |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 71301-82-1 |
| PubChem ID | 6604712 |
| InChI Key | DQLYTFPAEVJTFM-ZETCQYMHSA-N |
| Smiles | OC1=CC=CC([C@@](N)([H])C(O)=O)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| phosphate buffered saline | 8.36 | 50 | |
| 1eq. HCl | 16.72 | 100 | |
| 1eq. NaOH | 16.72 | 100 | |
| water | 8.36 | 50 |
Preparing Stock Solutions
The following data is based on the product molecular weight 167.16. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 5.98 mL | 29.91 mL | 59.82 mL |
| 5 mM | 1.2 mL | 5.98 mL | 11.96 mL |
| 10 mM | 0.6 mL | 2.99 mL | 5.98 mL |
| 50 mM | 0.12 mL | 0.6 mL | 1.2 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Birse et al (1993) Phenylglycine derivatives as new pharmacological tools for investigating the role of metabotropic glutamate receptors in the central nervous system. Neuroscience 52 481 PMID: 7680790
Hayashi et al (1994) Analysis of agonist and antagonist activities of phenylglycine derivatives for different cloned metabotropic glutamate receptor subtypes. J.Neurosci. 14 3370 PMID: 8182479
Keywords: (S)-3-Hydroxyphenylglycine, supplier, Group, I, mGlur, agonists, active, isomer, Receptors, mGlu1, mGlu5, mGluR1, mGluR5, Glutamate, Metabotropic, (S)-3H-PG, Glutamate, (Metabotropic), Group, I, Receptors, Glutamate, (Metabotropic), Group, I, Receptors, Tocris Bioscience
