BiologicalActivity
CBP/p300bromodomaininhibitor(IC50valuesare0.142-0.17and0.625μMforCBPandp300respectively).SelectiveforCBPandp300overATAD2,BAZ2B,BRD2(2),BRD4(1),PB1(5),PCAF,PHIP(2)andTIF1αbromodomainsinaBLIassay.AcceleratesFRAPrecoveryincellsataconcentrationof1μM.
LicensingInformation
ThisprobeissuppliedinconjunctionwiththeStructuralGenomicsConsortium.Forfurthercharacterizationdetails,pleasevisittheI-CBP112probesummaryontheSGCwebsite.
ExternalPortalInformation
Chemicalprobes.orgisaportalthatoffersindependentguidanceontheselectionand/orapplicationofsmallmoleculesforresearch.TheuseofI-CBP112isreviewedonthechemicalprobeswebsite.
CompoundLibraries
I-CBP112isalsoofferedaspartoftheTocriscreenPlusandTocriscreenEpigeneticsToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 468.59 |
| Formula | C27H36N2O5 |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 1640282-31-0 |
| PubChemID | 90488984 |
| InChIKey | YKNAKDFZAWQEEO-IBGZPJMESA-N |
| Smiles | COC(C(OC)=C1)=CC=C1C2=CC(OC[C@H]3CCCN(C)C3)=C(OCCN(C(CC)=O)C4)C4=C2 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solubility | Solubleto100mMinDMSOandto100mMin1eq.HCl |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight468.59.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.13mL | 10.67mL | 21.34mL |
| 5mM | 0.43mL | 2.13mL | 4.27mL |
| 10mM | 0.21mL | 1.07mL | 2.13mL |
| 50mM | 0.04mL | 0.21mL | 0.43mL |
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ProductDatasheets
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