BiologicalActivity
PotentandselectiveinhibitorofhumanNaV1.3andNaV1.1channels(IC50valuesare13and23nMrespectively).Exhibitsupto1,000foldselectivityagainstotherTTX-sensitiveorresistantsodiumchannels(IC50valuesare>10μMforhumanNaV1.5andNaV1.8channels).InteractswithaninhibitoryinteractionsitedistinctfromthoseboundbyTTXandlocalanesthetic-likemodulators.
CompoundLibraries
ICA121431isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 449.55 |
| Formula | C23H19N3O3S2 |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 313254-51-2 |
| PubChemID | 998021 |
| InChIKey | URSQNPPONHUJDL-UHFFFAOYSA-N |
| Smiles | O=S(C1=CC=C(NC(C(C4=CC=CC=C4)C3=CC=CC=C3)=O)C=C1)(NC2=NC=CS2)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 44.95 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight449.55.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.22mL | 11.12mL | 22.24mL |
| 5mM | 0.44mL | 2.22mL | 4.45mL |
| 10mM | 0.22mL | 1.11mL | 2.22mL |
| 50mM | 0.04mL | 0.22mL | 0.44mL |
MolarityCalculator
ReconstitutionCalculator
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ProductDatasheets
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