Biological Activity
Selective δ opioid antagonist. Exhibits partial agonist in vitro activity at δ receptors at high concentrations.
Licensing Information
Sold with the permission of AstraZeneca UK Ltd.
Technical Data
| M. Wt | 691.87 |
| Formula | C38H53N5O7 |
| Sequence |
YXXFL (Modifications: Tyr-1 = N,N-diallyl-Tyr, X = Aib) |
| Storage | Desiccate at -20°C |
| CAS Number | 89352-67-0 |
| PubChem ID | 44149909 |
| InChI Key | XUWLAGNFLUARAN-CHQNGUEUSA-N |
| Smiles | CC(C)C[C@H](NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)C(C)(C)NC(=O)C(C)(C)NC(=O)[C@H](CC1=CC=C(O)C=C1)N(CC=C)CC=C)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 69.19 mg/ml in DMSO and to 1 mg/ml in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 691.87. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.45 mL | 7.23 mL | 14.45 mL |
| 5 mM | 0.29 mL | 1.45 mL | 2.89 mL |
| 10 mM | 0.14 mL | 0.72 mL | 1.45 mL |
| 50 mM | 0.03 mL | 0.14 mL | 0.29 mL |
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References
References are publications that support the products' biological activity.
Cohen et al (1996) Opioid agonist activity of ICI 174864 and its carboxypeptidase degradation product, LY281217. J.Pharmacol.Exp.Ther. 238 769 PMID: 2875170
Cotton et al (1984) ICI-174,864: a highly selective antagonist for the opioid δ receptor. Eur.J.Pharmacol. 97 331 PMID: 6323195
Cowan et al (1985) Studies in vivo with ICI-174,864 and [D-Pen2,D-Pen5]-enkephalin. Neuropeptides 5 311 PMID: 2987731
Hirning et al (1985) Studies in vitro with ICI-174,864 [D-Pen2,D-Pen5]-enkephalin (DPDPE) and [D-Ala2,NMePhe4,Gly-ol]-enkephalin (DAGO). Neuropeptides 5 383 PMID: 2987739
Keywords: ICI 174,864, supplier, δ-opioid, delta-opioid, selective, peptide, antagonists, DOP, Receptors, OP1, ICI174864, AstraZeneca, Delta, Opioid, Receptors, Delta, Opioid, Receptors, Tocris Bioscience
