Biological Activity
Potent thromboxane A2 receptor (TP receptor) antagonist. Competitively inhibits contractile responses to U 46619 (Cat. No. 1932).
Licensing Information
Sold with the permission of AstraZeneca UK Ltd.
Compound Libraries
ICI 192,605 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 402.87 |
| Formula | C22H23ClO5 |
| Storage | Desiccate at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 117621-64-4 |
| PubChem ID | 6604763 |
| InChI Key | WHUIENZXNGAHQI-GKZDNZBASA-N |
| Smiles | OC(=O)CCC=C/C[C@@H]1CO[C@@H](O[C@@H]1C1=C(O)C=CC=C1)C1=C(Cl)C=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 40.29 | 100 | |
| ethanol | 40.29 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 402.87. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.48 mL | 12.41 mL | 24.82 mL |
| 5 mM | 0.5 mL | 2.48 mL | 4.96 mL |
| 10 mM | 0.25 mL | 1.24 mL | 2.48 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.5 mL |
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References
References are publications that support the products' biological activity.
Arakawa et al (1993) Leukotriene D4 and prostaglandin F2a- induced airflow obstruction and airway plasma exudation in guinea pig: role of thromboxane and its receptor. Br.J.Pharmacol. 110 127 PMID: 8220872
Brewster et al (1988) The synthesis of a novel thromboxane receptor antagonist 4(Z)-6-(2-o-chlorophenyl-4-o-hydroxyphenyl-1,3-dioxan-cis-5-yl)hexenoic acid ICI 192605. Prostaglandins 36 173 PMID: 2973084
Cao et al (2004) Thromboxane A2 (TP) receptor in the non-pregnant porcine myometrium and its role in regulation of spontaneous contractile activity. Eur.J.Pharmacol. 485 317 PMID: 14757156
Keywords: ICI 192,605, supplier, Potent, thromboxane, A2, TXA2, TP, receptor, antagonists, Prostanoid, prostaglandins, prostacyclins, eicosanoids, ICI192605, AstraZeneca, Prostanoid, Receptors, Prostanoid, Receptors, Tocris Bioscience
