Biological Activity
Highly potent κ agonist, 146-fold more active than U-50488 (Cat. No. 0495) in vitro.
Licensing Information
Sold with the permission of AstraZeneca UK Ltd.
Compound Libraries
ICI 199,441 hydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 427.8 |
| Formula | C21H24Cl2N2O.HCl |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 115199-84-3 |
| PubChem ID | 3082717 |
| InChI Key | VFLWVWZSDBTGQJ-VEIFNGETSA-N |
| Smiles | ClC1=C(Cl)C=C(CC(N([C@@]([H])([C@]3=CC=CC=C3)CN2CCCC2)C)=O)C=C1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 100 mM in DMSO and to 50 mM in ethanol |
Preparing Stock Solutions
The following data is based on the product molecular weight 427.8. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.34 mL | 11.69 mL | 23.38 mL |
| 5 mM | 0.47 mL | 2.34 mL | 4.68 mL |
| 10 mM | 0.23 mL | 1.17 mL | 2.34 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.47 mL |
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References
References are publications that support the products' biological activity.
Barlow et al (1991) Structure/activity studies related to 2-(3,4-dichlorophenyl)-N-methyl-N-[2-(1-pyrrolidinyl)-1-substituted-ethyl]acetamides: a novel series of potent and selective κ-opioid agonists. J.Med.Chem. 34 3149 PMID: 1659636
Costello et al (1991) 2-(3,4-Dichlorophenyl)-N-methyl-N-[2-(1-pyrrolidinyl)-1-substituted-ethyl]-acetamides: the use of conformational analysis in the development of a novel series of potent opioid κ agonists. J.Med.Chem. 34 181 PMID: 1846918
Keywords: ICI 199,441 hydrochloride, supplier, Potent, κ-opioid, kappa-opioid, agonists, KOP, Receptors, OP2, ICI199441, hydrochloride, AstraZeneca, Kappa, Opioid, Receptors, Kappa, Opioid, Receptors, Tocris Bioscience
