Biological Activity
Peripherally acting κ agonist.
Licensing Information
Sold with the permission of AstraZeneca UK Ltd.
Technical Data
| M. Wt | 501.84 |
| Formula | C23H26Cl2N2O4.HCl |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 121264-04-8 |
| PubChem ID | 129407 |
| InChI Key | FNDGLVOYAQNQPE-UHFFFAOYSA-N |
| Smiles | Cl.CN(C(CN1CCCC1)C1=CC(OCC(O)=O)=CC=C1)C(=O)CC1=CC(Cl)=C(Cl)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 100 mM in DMSO |
Preparing Stock Solutions
The following data is based on the product molecular weight 501.84. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.99 mL | 9.96 mL | 19.93 mL |
| 5 mM | 0.4 mL | 1.99 mL | 3.99 mL |
| 10 mM | 0.2 mL | 1 mL | 1.99 mL |
| 50 mM | 0.04 mL | 0.2 mL | 0.4 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Keïta et al (1995) Antinociceptive effect of a κ-opioid receptor agonist that minimally crosses the blood-brain barrier (ICI 204448) in a rat model of mononeuropathy. Eur.J.Pharmacol. 277 275 PMID: 7493620
Shaw et al (1989) ICI-204,448: a κ-opioid agonist with limited access to the CNS. Br.J.Pharmacol. 96 986 PMID: 2568146
Keywords: ICI 204,448 hydrochloride, supplier, κ-opioid, kappa-opioid, agonists, peripherally, KOP, Receptors, OP2, ICI204448, hydrochloride, AstraZeneca, Kappa, Opioid, Receptors, Kappa, Opioid, Receptors, Tocris Bioscience
