Biological Activity
Inhibits AMPA receptor desensitization and enhances cognition by a related mechanism. More able to cross the blood-brain barrier than cyclothiazide (Cat. No. 0713).
Compound Libraries
IDRA 21 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 232.68 |
| Formula | C8H9ClN2O2S |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 22503-72-6 |
| PubChem ID | 3688 |
| InChI Key | VZRNTCHTJRLTMU-UHFFFAOYSA-N |
| Smiles | CC1NC2=C(C=C(Cl)C=C2)S(=O)(=O)N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 100 mM in DMSO |
Preparing Stock Solutions
The following data is based on the product molecular weight 232.68. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.3 mL | 21.49 mL | 42.98 mL |
| 5 mM | 0.86 mL | 4.3 mL | 8.6 mL |
| 10 mM | 0.43 mL | 2.15 mL | 4.3 mL |
| 50 mM | 0.09 mL | 0.43 mL | 0.86 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Impagnatiello et al (1997) 7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine S,S-dioxide: a partial modulator of AMPA receptor desensitization devoid of neurotoxicity. Proc.Natl.Acad.Sci.U.S.A. 94 7053 PMID: 9192690
Thompson et al (1995) 7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine S,S-dioxide (IDRA 21), a congener of aniracetam, potently abates pharmacologically induced cognitive impairments in patas monkeys. Proc.Natl.Acad.Sci.U.S.A. 92 7667 PMID: 7644474
Zivkovic et al (1995) 7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine S,S-dioxide (IDRA 21): a benzothiadiazine derivative that enhances cognition by attenuating DL-α-amino-2,3-dihydro-5-methyl-3-oxo-4-isoxazolepropanoic acid (AMPA) receptor desensitization. J.Pharmacol.Exp.Ther. 272 300 PMID: 7815345
Keywords: IDRA 21, supplier, inhibitors, inhibits, AMPA, receptor, desensitization, desensitisation, Glutamate, Receptors, iGlur, Ionotropic, IDRA21, AMPA, Receptors, AMPA, Receptors, Tocris Bioscience
