Biological Activity
Voltage-dependent open-channel blocker of AMPA receptors. Selective between subtypes; blocks GluR2 subunit-lacking (Ca2+-permeable) receptors more potently than GluR2-containing receptors. Also potently blocks NMDA receptor channels. Less sensitive than IEM 1460 (Cat. No. 1460) at a holding potential between -40 and -80mV.
Technical Data
| M. Wt | 412.25 |
| Formula | C16H30N2.2HBr |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 162831-31-4 |
| PubChem ID | 9887867 |
| InChI Key | JMPHTNNJCZDROM-UHFFFAOYSA-N |
| Smiles | NCCCCCNCC1(CC3C2)CC(C3)CC2C1.Br.Br |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 100 mM in water and to 50 mM in DMSO |
Preparing Stock Solutions
The following data is based on the product molecular weight 412.25. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.43 mL | 12.13 mL | 24.26 mL |
| 5 mM | 0.49 mL | 2.43 mL | 4.85 mL |
| 10 mM | 0.24 mL | 1.21 mL | 2.43 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.49 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Magazanik et al (1997) Block of open channels of recombinant AMPA receptors and native AMPA/kainate receptors by adamantane derivatives. J.Physiol. 505 655 PMID: 9457643
Tikhonov et al (2000) Voltage-dependent block of native AMPA receptor channels by dicationic compounds. Br.J.Pharmacol. 129 265 PMID: 10694232
Keywords: IEM 1754 dihydrobromide, supplier, IEM1754, 2HBr, AMPA, receptor, blocker, blocks, AMPAR, voltage-dependent, AMPA, Receptors, AMPA, Receptors, Tocris Bioscience
