BiologicalActivity
HistonedemethylaseJMJDinhibitor(IC50valuesare0.12,0.17,0.2,0.3,0.6and1μMforJMJD3,JMJD1A,JMJD2A,JMJD2E,JMJD2CandUTXrespectively).Cellpermeable;inhibitsJMJD2A-mediatedH3K9me3demethylationinHeLacells.
LicensingInformation
ThiscompoundissuppliedinconjunctionwiththeStructuralGenomicsConsortium.Forfurthercharacterizationdetails,pleasevisittheIOX1summaryontheSGCwebsite.
CompoundLibraries
IOX1isalsoofferedaspartoftheTocriscreenPlusandTocriscreenEpigeneticsToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 189.17 |
| Formula | C10H7NO3 |
| Storage | Storeat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 5852-78-8 |
| PubChemID | 459617 |
| InChIKey | JGRPKOGHYBAVMW-UHFFFAOYSA-N |
| Smiles | OC2=CC=C(C(O)=O)C1=CC=CN=C12 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| 1eq.NaOH | 18.92 | 100 | |
| DMSO | 18.92 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight189.17.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 5.29mL | 26.43mL | 52.86mL |
| 5mM | 1.06mL | 5.29mL | 10.57mL |
| 10mM | 0.53mL | 2.64mL | 5.29mL |
| 50mM | 0.11mL | 0.53mL | 1.06mL |
MolarityCalculator
ReconstitutionCalculator
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ProductDatasheets
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