Biological Activity
Inhibitor of macrophage migration inhibitory factor (MIF). Acts as a suicide substrate to inactivate MIF catalytic and biological functions; inhibits MIF-associated liver enzyme activity in vivo. Also inhibits migration and anchorage independence of human lung adenocarcinoma cell lines in vitro.
Technical Data
| M. Wt | 282.08 |
| Formula | C10H7IN2 |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 41270-96-6 |
| PubChem ID | 817368 |
| InChI Key | ZTCJXHNJVLUUMR-UHFFFAOYSA-N |
| Smiles | IC1=NC=NC(C2=CC=CC=C2)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 28.21 | 100 | |
| ethanol | 14.1 | 50 |
Preparing Stock Solutions
The following data is based on the product molecular weight 282.08. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.55 mL | 17.73 mL | 35.45 mL |
| 5 mM | 0.71 mL | 3.55 mL | 7.09 mL |
| 10 mM | 0.35 mL | 1.77 mL | 3.55 mL |
| 50 mM | 0.07 mL | 0.35 mL | 0.71 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Winner et al (2008) A novel, macrophage migration inhibitory factor suicide substrate inhibits motility and growth of lung cancer cells. Cancer Res. 68 7253 PMID: 18794110
Keywords: 4-IPP, supplier, macrophage, migration, inhibitory, factors, MIF, inhibitors, inhibits, suicide, substrates, cytokines, 4IPP, Cytokines, Cytokines, Tocris Bioscience
