Biological Activity
JNK inhibitor (Kd values are 87, 360 and 390 nM for JNK3, JNK2 and JNK1, respectively). Inhibits LPS-induced proinflammatory cytokine and nitric oxide production in vitro. Attenuates collagen-induced arthritis severity and inhibits murine delayed-type hypersensitivity in vivo. Anti-inflammatory and immunosuppressive. Also releases NO upon metabolism by liver microsomes.
Technical Data
| M. Wt | 269.23 |
| Formula | C15H8N3NaO |
| Storage | Store at -20°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 1421610-21-0 |
| PubChem ID | 72193876 |
| InChI Key | JBNHEGDICQSOLR-NYAKATHWSA-M |
| Smiles | [Na]O/N=C1C2=NC3=CC=CC=C3N=C2C4=C1C=CC=C4 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 5.38 | 20mM with gentle warming |
Preparing Stock Solutions
The following data is based on the product molecular weight 269.23. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.71 mL | 18.57 mL | 37.14 mL |
| 5 mM | 0.74 mL | 3.71 mL | 7.43 mL |
| 10 mM | 0.37 mL | 1.86 mL | 3.71 mL |
| 50 mM | 0.07 mL | 0.37 mL | 0.74 mL |
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References
References are publications that support the products' biological activity.
Schepetkin et al (2015) Anti-Inflammatory effects and joint protection in collagen-induced arthritis after treatment with IQ-1S, a selective c-Jun N-terminal kinase Inhibitor. J.Pharmacol.Exp.Ther. 353 505 PMID: 25784649
Schepetkin et al (2012) Identification and characterization of a novel class of c-Jun N-terminal kinase inhibitors. Mol.Pharmacol. 81 832 PMID: 22434859
Atochin et al (2016) A novel dual NO-donating oxime and c-Jun N-terminal kinase inhibitor protects against cerebral ischemia-reperfusion injury in mice. Neurosci.Lett. 618 45 PMID: 26923672
Keywords: IQ 1S, supplier, IQ1S, JNK, inhibitors, inhibits, anti-inflammatory, immunosuppresents, NO, donor, JNK/c-jun, ROS, Donors, JNK/c-jun, Tocris Bioscience
