Biological Activity
Selective JNK3 inhibitor (Kd values are 66, 240 and 290 nM for JNK3, JNK1 and JNK2 respectively). Inhibits NF-κB/AP1 transcriptional activity in THP1-Blue cells (IC50 = 1.4 μM). Also inhibits TNF-α and IL-6 production in vitro.
Technical Data
| M. Wt | 341.32 |
| Formula | C20H11N3O3 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 312538-03-7 |
| PubChem ID | 777728 |
| InChI Key | WBSWWONMTZEOGS-UHFFFAOYSA-N |
| Smiles | O=C(C5=CC=CO5)O/N=C3C2=NC1=CC=CC=C1N=C2C4=C/3C=CC=C4 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 6.83 | 20 |
Preparing Stock Solutions
The following data is based on the product molecular weight 341.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.93 mL | 14.65 mL | 29.3 mL |
| 5 mM | 0.59 mL | 2.93 mL | 5.86 mL |
| 10 mM | 0.29 mL | 1.46 mL | 2.93 mL |
| 50 mM | 0.06 mL | 0.29 mL | 0.59 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Schepetkin et al (2012) Identification and characterization of a novel class of c-Jun N-terminal kinase inhibitors. Mol.Pharmacol. 81 832 PMID: 22434859
Keywords: IQ 3, supplier, IQ3, Selective, JNK, inhibitors, inhibits, JNK1, JNK2, JNK3, IQ3, JNK/c-jun, c-jun, MAPK, kinases, JNK/c-jun, JNK/c-jun, Tocris Bioscience
