Biological Activity
IRAK4 and IRAK1 inhibitor (IC50 values are 0.2 and 0.3 μM, respectively).
Technical Data
| M. Wt | 395.41 |
| Formula | C20H21N5O4 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 509093-47-4 |
| PubChem ID | 11983295 |
| InChI Key | QTCFYQHZJIIHBS-UHFFFAOYSA-N |
| Smiles | O=C(NC1=NC(C=CC=C2)=C2N1CCN3CCOCC3)C4=CC=CC([N+]([O-])=O)=C4 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 7.91 | 20 |
Preparing Stock Solutions
The following data is based on the product molecular weight 395.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.53 mL | 12.65 mL | 25.29 mL |
| 5 mM | 0.51 mL | 2.53 mL | 5.06 mL |
| 10 mM | 0.25 mL | 1.26 mL | 2.53 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.51 mL |
Molarity Calculator
Reconstitution Calculator
Dilution Calculator
Product Datasheets
References
References are publications that support the products' biological activity.
Powers et al (2006) Discovery and initial SAR of inhibitors of interleukin-1 receptor-associated kinase-4. Bioorg.Med.Chem.Lett. 16 2842 PMID: 16563752
Keywords: IRAK1/4 Inhibitor I, supplier, IRAK1/4, inhibitors, inhibits, I, interleukin-1, receptor, associated, kinase, IRAK, IRAK, Tocris Bioscience
