Biological Activity
ETB endothelin receptor antagonist.
Technical Data
| M. Wt | 1410 |
| Formula | C68H92N14O15S2 |
| Sequence |
CVYFCHLDIIW (Modifications: Disulfide bridge between 1 - 5) |
| Storage | Desiccate at -20°C |
| CAS Number | 144602-02-8 |
| PubChem ID | 16142511 |
| InChI Key | OETKRDJJNWJFOP-PJLZVMSOSA-N |
| Smiles | [H]N[C@H]1CSSC[C@H](NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CC2=CC=C(O)C=C2)NC(=O)[C@@H](NC1=O)C(C)C)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 1 mg/ml in 20% acetonitrile |
Preparing Stock Solutions
The following data is based on the product molecular weight 1410. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.71 mL | 3.55 mL | 7.09 mL |
| 5 mM | 0.14 mL | 0.71 mL | 1.42 mL |
| 10 mM | 0.07 mL | 0.35 mL | 0.71 mL |
| 50 mM | 0.01 mL | 0.07 mL | 0.14 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Haynes et al (1993) Endothelin; progress in pharmacology and physiology. TiPS 14 225 PMID: 8372400
Karaki et al (1993) ETB receptor antagonist, IRL 1038, selectively inhibits the endothelin-induced endothelium-dependent vascular relaxation. Eur.J.Pharmacol. 231 371 PMID: 8449230
Keywords: IRL-1038, supplier, ETB, antagonists, Receptors, Endothelin, Endothelin, ETB, Receptors, Endothelin, ETB, Receptors, Tocris Bioscience
