Biological Activity
High affinity A2B receptor antagonist (Ki = 3.49 nM). Exhibits >1000-fold selectivity for A2B over A1, A2A and A3 receptors.
Technical Data
| M. Wt | 337.37 |
| Formula | C19H19N3O3 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 932191-62-3 |
| PubChem ID | 17198004 |
| InChI Key | NYHLRBMDXQBOIB-UHFFFAOYSA-N |
| Smiles | CC(OC(C1=C(N=C2NC3=CC=CC=C3N2C1C4=CC=CO4)C)=O)C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 6.75 | 20 | |
| ethanol | 1.69 | 5mM with gentle warming |
Preparing Stock Solutions
The following data is based on the product molecular weight 337.37. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.96 mL | 14.82 mL | 29.64 mL |
| 5 mM | 0.59 mL | 2.96 mL | 5.93 mL |
| 10 mM | 0.3 mL | 1.48 mL | 2.96 mL |
| 50 mM | 0.06 mL | 0.3 mL | 0.59 mL |
Molarity Calculator
Reconstitution Calculator
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Product Datasheets
References
References are publications that support the products' biological activity.
El Maatougui et al (2016) Discovery of potent and highly selective A2B adenosine receptor antagonist chemotypes. J.Med.Chem. 59 1967 PMID: 26824742
Keywords: ISAM 140, supplier, ISAM140, high, affinity, adenosine, receptors, A2B, selective, Adenosine, A2B, Receptors, Adenosine, A2B, Receptors, Tocris Bioscience
