Biological Activity
c-Rel inhibitor (IC50 = 3 μM). Inhibits IL-2 expression in activated T-cells in vitro. Reduces severity of graft-versus-host disease following hematopoietic stem cell transplant (HSCT) and inhibits growth of human B-cell lymphoma xenografts in mice. Inhibits the oxidative stress response in lymphoma cells.
Technical Data
| M. Wt | 342.37 |
| Formula | C17H14N2O4S |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1584121-99-2 |
| PubChem ID | 90082813 |
| InChI Key | JHOPCCOYRKEHQU-UHFFFAOYSA-N |
| Smiles | COC1=C(C=CC=C2)C2=C(/C=C3C(NC(NC/3=O)=S)=O)C(OC)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 34.24 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 342.37. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.92 mL | 14.6 mL | 29.21 mL |
| 5 mM | 0.58 mL | 2.92 mL | 5.84 mL |
| 10 mM | 0.29 mL | 1.46 mL | 2.92 mL |
| 50 mM | 0.06 mL | 0.29 mL | 0.58 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Shono et al (2016) Characterization of a c-Rel inhibitor that mediates anticancer properties in hematologic malignancies by blocking NF-κB-controlled oxidative stress responses. Cancer Res. 76 377 PMID: 26744524
Keywords: IT 901, supplier, IT901, NF-KB, NF-KappaB, NF-κB, c-Rel, subunit, inhibitors, inhibits, oxidative, stress, response, anticancer, NF-kB/IkB, NF-kB/IkB, Tocris Bioscience
