BiologicalActivity
SelectiveinhibitorofTGF-βsignaling(IC50=0.85μM);displayslittleornoinhibitionofactivin,WntorBMPsignalingpathways.InducesproteasomaldegradationoftheTGF-βtypeIIreceptor.InhibitsTGF-β-inducedmesodermformationfrommouseembryonicstemcells(ESCs)duringearlydifferentiation;selectivelypromotesthedifferentiationofESCstocardiomyocytesinvitrobetweendays3-5.Doesnotinducedifferentiationofvascularsmoothmusclecellsorendothelialcells.
CompoundLibraries
ITD1isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 415.52 |
| Formula | C27H29NO3 |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 1099644-42-4 |
| PubChemID | 44135961 |
| InChIKey | ULFUJLFTRWWLPO-UHFFFAOYSA-N |
| Smiles | CC(C3)(C)CC(C1=C3NC(C)=C(C(OCC)=O)C1C2=CC=C(C4=CC=CC=C4)C=C2)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 8.31 | 20 | |
| ethanol | 4.16 | 10mMwithgentlewarming |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight415.52.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.41mL | 12.03mL | 24.07mL |
| 5mM | 0.48mL | 2.41mL | 4.81mL |
| 10mM | 0.24mL | 1.2mL | 2.41mL |
| 50mM | 0.05mL | 0.24mL | 0.48mL |
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ProductDatasheets
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