Biological Activity
Non-steroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase 1 and cyclooxygenase 2 (IC50 values are 12 and 80 μM respectively). Active isomer of ibuprofen.
Compound Libraries
(S)-(+)-Ibuprofen is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 206.28 |
| Formula | C13H18O2 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 51146-56-6 |
| PubChem ID | 39912 |
| InChI Key | HEFNNWSXXWATRW-JTQLQIEISA-N |
| Smiles | CC(C)CC1=CC=C([C@H](C)C(O)=O)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 20.63 | 100 | |
| ethanol | 20.63 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 206.28. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.85 mL | 24.24 mL | 48.48 mL |
| 5 mM | 0.97 mL | 4.85 mL | 9.7 mL |
| 10 mM | 0.48 mL | 2.42 mL | 4.85 mL |
| 50 mM | 0.1 mL | 0.48 mL | 0.97 mL |
Molarity Calculator
Reconstitution Calculator
Dilution Calculator
Product Datasheets
References
References are publications that support the products' biological activity.
Kato et al (2001) Cyclooxygenase-1 and cyclooxygenase-2 selectivity of non-steroidal anti-inflammatory drugs: investigation using human peripheral monocytes. J.Pharm.Pharmacol. 53 1679 PMID: 11804398
Keywords: (S)-(+)-Ibuprofen, supplier, Cyclooxygenase, inhibitors, inhibits, COX-1, COX-2, Oxygenases, Oxidases, Cyclooxygenase, Cyclooxygenase, Tocris Bioscience
