Biological Activity
α2-adrenoceptor antagonist, and I2 ligand, selective over I1 sites (pKi values are 5.90, 7.22, 8.01, 7.43, and 7.7 for I1, I2, α2A, α2B, and α2C receptors respectively).
Technical Data
| M. Wt | 240.69 |
| Formula | C11H12N2O2.HCl |
| Storage | Store at RT |
| Purity | ≥98% |
| CAS Number | 79944-56-2 |
| PubChem ID | 154494 |
| InChI Key | MYUBYOVCLMEAOH-UHFFFAOYSA-N |
| Smiles | Cl.C1CN=C(N1)C1COC2=CC=CC=C2O1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| phosphate buffered saline | 12.03 | 50 | |
| water | 24.07 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 240.69. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.15 mL | 20.77 mL | 41.55 mL |
| 5 mM | 0.83 mL | 4.15 mL | 8.31 mL |
| 10 mM | 0.42 mL | 2.08 mL | 4.15 mL |
| 50 mM | 0.08 mL | 0.42 mL | 0.83 mL |
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References
References are publications that support the products' biological activity.
Berdeu et al (1995) Evidence for two different imidazoline sites on pancreatic B cells and vascular bed in rat. Eur.J.Pharmacol. 275 91 PMID: 7774667
Dabir (1986) Idazoxan: a novel pharmacological tool for the study of α2-adrenoceptors. J.Pharmacol. 17 113 PMID: 2875218
Eglen et al (1998) 'Seeing through a glass darkly': casting light on imidazoline 'I' sites. TiPS 19 381 PMID: 9786027
Michel and Ernsberger (1992) Keeping an eye on the I site: imidazoline-preferring receptors. TIPS 13 369 PMID: 1413085
Keywords: Idazoxan hydrochloride, supplier, α2-adrenoceptor, alpha2-adrenoceptor, a2-adrenoceptor, a2-adrenergic, α2-Adrenergic, alpha2-Adrenergic, antagonists, I2, ligand, Receptors, Imidazoline, RX781094, RX, 781094, I2, Receptors, Adrenergic, Alpha-2, Receptors, Adrenergic, Alpha-2, Receptors, Tocris Bioscience
