Biological Activity
NMDA receptor antagonist, acting at the polyamine site. Also an α-adrenergic vasodilator. σ2 ligand displaying about 3-fold selectivity over σ1 sites.
Technical Data
| M. Wt | 400.49 |
| Formula | C21H27NO2.½C4H6O6 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 23210-56-2 |
| PubChem ID | 3689 |
| InChI Key | UYNVMODNBIQBMV-UHFFFAOYSA-N |
| Smiles | OC(C=C3)=CC=C3[C@@H](O)[C@H](C)N2CCC(CC2)CC1=CC=CC=C1.OC(C=C6)=CC=C6[C@@H](O)[C@H](C)N5CCC(CC5)CC4=CC=CC=C4.O=C(O)C(O)C(O)C(O)=O.OC(C=C9)=CC=C9[C@H](O)[C@@H](C)N8CCC(CC8)CC7=CC=CC=C7.OC(C=C%12)=CC=C%12[C@H](O)[C@@H](C)N%11CCC(CC%11)CC%10=CC=CC=C%10.O=C(O)C(O)C(O)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 40.05 | 100 | |
| ethanol | 40.05 | 100 | |
| water | 6.01 | 15mM with gentle warming |
Preparing Stock Solutions
The following data is based on the product molecular weight 400.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.5 mL | 12.48 mL | 24.97 mL |
| 5 mM | 0.5 mL | 2.5 mL | 4.99 mL |
| 10 mM | 0.25 mL | 1.25 mL | 2.5 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.5 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Gotti et al (1988) Ifenprodil and SL-82,0715 as cerebral anti-ischemic agents. 1. Evidence for efficacy in models of focal cerebral ischemia. J.Pharmacol.Exp.Ther. 247 1211 PMID: 2849668
Schoemaker et al (1990) Polyamine-sensitive binding of [3H]ifenprodil, a novel NMDA antagonist to the rat cerebral cortex. Eur.J.Pharmacol. 176 249 PMID: 2178949
Reynolds and Miller (1989) Ifenprodil is a novel type of N-methyl-D-aspartate receptor antagonist: interaction with polyamines. Mol.Pharmacol. 36 758 PMID: 2555674
Shalaby et al (1992) Neuroprotective effects of the N-methyl-D-aspartate receptor antagonists ifenprodil and SL-82,0715 on hippocampal cells in culture. J.Pharmacol.Exp.Ther. 260 925 PMID: 1346650
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