BiologicalActivity
Potentandselectivev-Abltyrosinekinaseinhibitor(IC50=38nM).AlsoinhibitsPDGFRandc-kit.Exhibitsselectivityforv-Abloverapanelofothertyrosineandserine/threonineproteinkinases.SelectivelyinhibitsPDGF-stimulatedgrowthofv-abl-transformedPB-3cellsandv-sis-transformedBALB/c3T3cellsinvitro.ExhibitsantitumoreffectsinmicebearingAMuLVorBABL/c3T3v-siscells.
ExternalPortalInformation
Chemicalprobes.orgisaportalthatoffersindependentguidanceontheselectionand/orapplicationofsmallmoleculesforresearch.TheuseofImatinibisreviewedonthechemicalprobeswebsite.
CompoundLibraries
ImatinibmesylateisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 589.71 |
| Formula | C29H31N7O.CH4O3S |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 220127-57-1 |
| PubChemID | 123596 |
| InChIKey | YLMAHDNUQAMNNX-UHFFFAOYSA-N |
| Smiles | CS(O)(=O)=O.CN1CCN(CC1)CC2=CC=C(C(NC3=CC=C(C(NC4=NC=CC(C5=CN=CC=C5)=N4)=C3)C)=O)C=C2 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 58.97 | 100 | |
| water | 58.97 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight589.71.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.7mL | 8.48mL | 16.96mL |
| 5mM | 0.34mL | 1.7mL | 3.39mL |
| 10mM | 0.17mL | 0.85mL | 1.7mL |
| 50mM | 0.03mL | 0.17mL | 0.34mL |
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