Biological Activity
An inhibitor of NO synthases, more potent than NG-methyl-L-arginine and selective for iNOS.
Technical Data
| M. Wt | 134.61 |
| Formula | C5H10N2.HCl |
| Storage | Desiccate at RT |
| CAS Number | 16011-96-4 |
| PubChem ID | 85236 |
| InChI Key | ZHDTXTDHBRADLM-UHFFFAOYSA-N |
| Smiles | N=C1NCCCC1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 100 mM in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 134.61. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 7.43 mL | 37.14 mL | 74.29 mL |
| 5 mM | 1.49 mL | 7.43 mL | 14.86 mL |
| 10 mM | 0.74 mL | 3.71 mL | 7.43 mL |
| 50 mM | 0.15 mL | 0.74 mL | 1.49 mL |
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Product Datasheets
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References
References are publications that support the products' biological activity.
Moore et al (1996) 2-Iminopiperidine and other 2-iminoazaheterocycles as potent inhibitors of human nitric oxide synthase isoforms. J.Med.Chem. 39 669 PMID: 8576908
Moore and Handy (1997) Selective inhibitors of neuronal nitric oxide synthase - is no NOS really good NOS for the nervous system? TiPS 18 204 PMID: 9226999
Southan et al (1995) Amidines are potent inhibitors of nitric oxide synthases: preferential inhibition of the inducible isoform. Eur.J.Pharmacol. 291 311 PMID: 8719415
Keywords: 2-Iminopiperidine hydrochloride, supplier, Selective, iNOS, inhibitors, inhibits, Nitric, Oxide, Signaling, Signalling, Inducible, NO, Synthases, iNOS, iNOS, Tocris Bioscience
