BiologicalActivity
PotentGABAAreceptorpositiveallostericmodulatorthatactsatthebenzodiazepinesite(Kivaluesare1.2and1.7nMinratfrontalcortexandcerebellumrespectively).Displays~10-foldselectivityforα1subunit-containingreceptors(EC50valuesare2.6,24,60and77nMforα1β2γ2,α2β2γ2,α3β3γ2andα5β2γ2receptorsrespectively).Exhibitssedative,hypnotic,anxiolyticandanticonvulsantactivityinvivoandisorallyactive.
CompoundLibraries
IndiplonisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 376.43 |
| Formula | C20H16N4O2S |
| Storage | Storeat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 325715-02-4 |
| PubChemID | 6450813 |
| InChIKey | CBIAWPMZSFFRGN-UHFFFAOYSA-N |
| Smiles | CN(C(C)=O)C1=CC=CC(C3=CC=NC2=C(C(C4=CC=CS4)=O)C=NN23)=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 18.82 | 50 | |
| ethanol | 1.88 | 5 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight376.43.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.66mL | 13.28mL | 26.57mL |
| 5mM | 0.53mL | 2.66mL | 5.31mL |
| 10mM | 0.27mL | 1.33mL | 2.66mL |
| 50mM | 0.05mL | 0.27mL | 0.53mL |
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ProductDatasheets
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