Biological Activity
Precursor to the highly potent and selective ligand for the α4β2 nicotinic receptor, 5-Iodo-A-85380 (Cat. No.1518). Suitable for radioiodination.
Technical Data
| M. Wt | 427.11 |
| Formula | C17H28N2O3Sn |
| Storage | Desiccate at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 213766-21-3 |
| PubChem ID | 10574471 |
| InChI Key | HHNYNAVVSDTMQD-HZAYLZKLSA-N |
| Smiles | O=C(N1[C@H](COC2=CC([Sn](C)(C)C)=CN=C2)CC1)OC(C)(C)C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble in ethanol and in DMSO |
Preparing Stock Solutions
The following data is based on the product molecular weight 427.11. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.34 mL | 11.71 mL | 23.41 mL |
| 5 mM | 0.47 mL | 2.34 mL | 4.68 mL |
| 10 mM | 0.23 mL | 1.17 mL | 2.34 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.47 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Koren et al (1998) 2-, 5-, and 6-Halo-3-(2(S)-azetidinylmethoxy)pyridines: synthesis, affinity for nicotinic acetylcholine receptors, and molecular modeling. J.Med.Chem. 41 3690 PMID: 9733494
Mukhin et al (2000) 5-Iodo-A-85380, an α4β2 subtype-selective ligand for nicotinic acetylcholine receptors. Mol.Pharmacol. 57 642 PMID: 10692507
Keywords: 5-Iodo-A-85380, 5-trimethylstannyl N-BOC derivative, supplier, Precursor, α4β2, a4b2, Nicotinic, Receptors, Acetylcholine, nAChR, Non-Selective, Subtypes, Other, 5-Iodo-A-853805-trimethylstannyl, N-BOC, derivative, Nicotinic, Receptors, (Other, Subtypes), Nicotinic, (a4b2), Receptors, Nicotinic, (a4b2), Receptors, Tocris Bioscience
