BiologicalActivity
Potentadenosinekinaseinhibitor(IC50=26nM).Alsonucleosidetransporterinhibitor(IC50valuesare<25nM,7μMand15μMforinhibitionof[3H]adenosine,[3H]uridineand[3H]formycinBuptakerespectively).Stronglystimulatesglycogensynthesisinhepatocytesviaactivationofglycogensynthase.AlsoinhibitsCK1,insulinreceptortyrosinekinase,phosphorylasekinase,PKA,CK2andPKC(IC50valuesare0.4,3.5,5-10,5-10,10.9and27.7μMrespectively).DecreaseshippocampalDNAmethylationthroughadenosinekinaseinhibitioninvivo.
TechnicalData
| M.Wt | 392.15 |
| Formula | C11H13IN4O4 |
| Storage | Storeat-20°C |
| Purity | ≥90%(HPLC) |
| CASNumber | 24386-93-4 |
| PubChemID | 97297 |
| InChIKey | WHSIXKUPQCKWBY-IOSLPCCCSA-N |
| Smiles | O[C@H]([C@H](O)[C@@H](CO)O3)[C@@H]3N1C2=C(C(N)=NC=N2)C(I)=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 19.61 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight392.15.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.55mL | 12.75mL | 25.5mL |
| 5mM | 0.51mL | 2.55mL | 5.1mL |
| 10mM | 0.26mL | 1.28mL | 2.55mL |
| 50mM | 0.05mL | 0.26mL | 0.51mL |
MolarityCalculator
ReconstitutionCalculator
DilutionCalculator
ProductDatasheets
本网站将在规定时间内给予删除等相关处理。
