Biological Activity
5-HT1B antagonist, approximately 30-fold selective over 5-HT1A. Also possesses affinity for β-adrenergic receptors.
Technical Data
| M. Wt | 332.4 |
| Formula | C16H22N2O2.½C4H4O4 |
| Storage | Desiccate at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 874882-92-5 |
| PubChem ID | 45073435 |
| InChI Key | MCHSBYUSDSJLAQ-WXXKFALUSA-N |
| Smiles | [H]OC(=O)C=CC(=O)O[H].CC(C)NCC(O)COC1=CC=CC=C1N1C=CC=C1.CC(C)NCC(O)COC1=CC=CC=C1N1C=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| phosphate buffered saline | 3.32 | 10mM with gentle warming | |
| water | 3.32 | 10mM with gentle warming |
Preparing Stock Solutions
The following data is based on the product molecular weight 332.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.01 mL | 15.04 mL | 30.08 mL |
| 5 mM | 0.6 mL | 3.01 mL | 6.02 mL |
| 10 mM | 0.3 mL | 1.5 mL | 3.01 mL |
| 50 mM | 0.06 mL | 0.3 mL | 0.6 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Waldmeier et al (1988) Interactions of isamoltane (CGP 361A), an anxiolytic phenoxypropanolamine derivative, with 5-HT1 receptor subtypes in the rat brain. Naunyn Schmiedebergs Arch.Pharmacol. 337 609 PMID: 2905765
Keywords: Isamoltane hemifumarate, supplier, 5-HT1B, antagonist, Serotonin, Receptors, 5-HT1B, Receptors, 5-HT1B, Receptors, Tocris Bioscience
