Biological Activity
Potent inhibitor of NO synthase, with selectivity for the inducible form.
Technical Data
| M. Wt | 199.11 |
| Formula | C4H10N2S.HBr |
| Storage | Store at RT |
| CAS Number | 4269-97-0 |
| PubChem ID | 9813062 |
| InChI Key | SLGVZEOMLCTKRK-UHFFFAOYSA-N |
| Smiles | Br.CC(C)SC(=N)N |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 19.91 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 199.11. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 5.02 mL | 25.11 mL | 50.22 mL |
| 5 mM | 1 mL | 5.02 mL | 10.04 mL |
| 10 mM | 0.5 mL | 2.51 mL | 5.02 mL |
| 50 mM | 0.1 mL | 0.5 mL | 1 mL |
Molarity Calculator
Reconstitution Calculator
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Product Datasheets
References
References are publications that support the products' biological activity.
Garvey et al (1994) Potent and selective inhibition of human nitric oxide synthases. J.Biol.Chem. 269 26669 PMID: 7523409
Moore and Handy (1997) Selective inhibitors of neuronal nitric oxide synthase - is no NOS really good NOS for the nervous system? TiPS 18 204 PMID: 9226999
Handy et al (1995) Effect of S-methylisothiourea on neuronal nitric oxide synthase, nociception and blood pressure in the mouse. Br.J.Pharmacol. 115 68P PMID:
Keywords: S-Isopropylisothiourea hydrobromide, supplier, iNOS, inhibitors, inhibits, arginine, binding, site, Nitric, Oxide, Signaling, Signalling, Inducible, NO, Synthases, iNOS, iNOS, Tocris Bioscience
