BiologicalActivity
PotentandselectiveL-typevoltage-gatedCa2+channelblocker.EC50andpA2valuesare1.4nMand10.3forrelaxationofdepolarization-andCa2+-inducedcontractionsofrabbitaortarespectively;EC25=0.45nMforreductioninrateofspontaneouslybeatingguineapigrightatria.Long-actingantihypertensiveagentinvivo,exertingprimaryeffectsonvasculartissuewithsecondarynegativechronotropicaction.
CompoundLibraries
IsradipineisalsoofferedaspartoftheTocriscreenPlusandTocriscreenLibraryofFDA-ApprovedCompounds.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 371.39 |
| Formula | C19H21N3O5 |
| Storage | StoreatRT |
| Purity | ≥99%(HPLC) |
| CASNumber | 75695-93-1 |
| PubChemID | 3784 |
| InChIKey | HMJIYCCIJYRONP-UHFFFAOYSA-N |
| Smiles | COC(=O)C1=C(C)NC(C)=C(C1C1=CC=CC2=NON=C12)C(=O)OC(C)C |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 18.57 | 50 | |
| ethanol | 7.43 | 20 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight371.39.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.69mL | 13.46mL | 26.93mL |
| 5mM | 0.54mL | 2.69mL | 5.39mL |
| 10mM | 0.27mL | 1.35mL | 2.69mL |
| 50mM | 0.05mL | 0.27mL | 0.54mL |
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