BiologicalActivity
Potentneuroprotectiveandneurotrophiccompound.Protectsagainstneurotoxicityincorticalneuronsinvitro(EC50=25-200nM).ReducessolubleAβ40andAβ42levelsandincreasesBDNFlevelsinthehippocampusinvivo.Enhancesmemoryinwildtyperats.PreventsmemorydeficitsandrescuescognitivedeficitsinyoungandagedtransgenicAlzheimer'sdiseasemice,respectively.Orallyactive.
LicensingInformation
SoldforresearchuseonlyunderlicensefromtheSalkInstituteforBiologicalStudies
TechnicalData
| M.Wt | 350.33 |
| Formula | C18H17F3N2O2 |
| Storage | Storeat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 1146963-51-0 |
| PubChemID | 25229652 |
| InChIKey | HYMZAYGFKNNHDN-SSDVNMTOSA-N |
| Smiles | O=C(C(F)(F)F)N(C2=C(C)C=C(C)C=C2)/N=C/C1=CC=CC(OC)=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 35.03 | 100 | |
| ethanol | 35.03 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight350.33.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.85mL | 14.27mL | 28.54mL |
| 5mM | 0.57mL | 2.85mL | 5.71mL |
| 10mM | 0.29mL | 1.43mL | 2.85mL |
| 50mM | 0.06mL | 0.29mL | 0.57mL |
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