Biological Activity
Peptide inhibitor of c-Jun N-terminal kinase (JNK), based on residues 153-163 of JNK-interacting protein-1 (JIP-1). Binds to JNK with affinity in the micromolar range and minimally inhibits p38 and ERK.
Technical Data
| M. Wt | 1341.6 |
| Formula | C61H104N20O14 |
| Sequence |
RPKRPTTLNLF (Modifications: Phe-11 = C-terminal amide) |
| Storage | Desiccate at -20°C |
| CAS Number | 438567-88-5 |
| PubChem ID | 90479803 |
| InChI Key | BWQKOFMNXWAKES-QHYOMBHZSA-N |
| Smiles | [H]N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 1 mg/ml in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 1341.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.75 mL | 3.73 mL | 7.45 mL |
| 5 mM | 0.15 mL | 0.75 mL | 1.49 mL |
| 10 mM | 0.07 mL | 0.37 mL | 0.75 mL |
| 50 mM | 0.01 mL | 0.07 mL | 0.15 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Barr et al (2002) Identification of the critical features of a small peptide inhibitor of JNK activity. J.Biol.Chem. 277 10987 PMID: 11790767
Keywords: JIP-1 (153-163), supplier, JNK-selective, inhibitors, inhibits, peptide, c-Jun, N-Terminal, Kinase, SAPKs, Stress-Activated, Protein, MAPK, Mitogen-Activated, protein, TIJIP, TI-JIP, JNK/c-jun, JNK/c-jun, Tocris Bioscience
