BiologicalActivity
Potentdownstreamhedgehog(Hh)signalinginhibitorthatpreventsGli-dependenttranscriptionalactivity(IC50=30nM).Exhibitsantiproliferativeactivityinarangeofcancercelllines(GI50=3-21nM)andinhumanxenograftsinvivo.Inhibitsalcoholdehydrogenase7(Adh7)(IC50=210nM)andactsasamicrotubuledepolymerizingagentinvitro.
CompoundLibraries
JK184isalsoofferedaspartoftheTocriscreenPlusandTocriscreenStemCellToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 350.44 |
| Formula | C19H18N4OS |
| Storage | Storeat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 315703-52-7 |
| PubChemID | 1069686 |
| InChIKey | ROYXIPOUVGDTAO-UHFFFAOYSA-N |
| Smiles | CC2=C(C3=CSC(NC4=CC=C(OCC)C=C4)=N3)N1C=CC=CC1=N2 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 35.04 | 100 | |
| ethanol | 8.76 | 25 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight350.44.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.85mL | 14.27mL | 28.54mL |
| 5mM | 0.57mL | 2.85mL | 5.71mL |
| 10mM | 0.29mL | 1.43mL | 2.85mL |
| 50mM | 0.06mL | 0.29mL | 0.57mL |
MolarityCalculator
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ProductDatasheets
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