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Tocris Bioscience(优势品牌)
主营:主营:分子类,蛋白类,抗体类,生化类试剂
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4000-520-616
当前位置: 首页 > 产品中心 > protease > Tocris/JLK 6/2677/10/10毫克
商品详细Tocris/JLK 6/2677/10/10毫克
Tocris/JLK 6/2677/10/10毫克
Tocris/JLK 6/2677/10/10毫克
商品编号: 2677/10
品牌: Tocris Bioscience
市场价: ¥2980.00
美元价: 1788.00
产地: 美国(厂家直采)
公司:
产品分类: 蛋白酶类
公司分类: protease
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
Description:Inhibitorofγ-secretase-mediatedβAPPprocessing
ChemicalName:7-Amino-4-chloro-3-methoxy-1H-2-benzopyran
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Inhibitorofγ-secretasethatselectivelyinhibitsβAPPcleavagewithoutaffectingotherγ-secretase-mediatedpathways.PreventsrecoveryofAβ40andAβ42fromHEK293celloverexpressingwild-typeorSwedish-mutatedβAPP(IC50~30μM)butdisplaysnoeffectonNotchcleavageandNotch-mediatedintracellularsignaling.DisplaysnoactivityonBACE1,BACE2,α-secretase,theproteosomeorGSK3β.

TechnicalData

M.Wt225.63
FormulaC10H8ClNO3
StorageStoreatRT
Purity≥99%(HPLC)
CASNumber62252-26-0
PubChemID3803
InChIKeyAMDGKLWVCUXONP-UHFFFAOYSA-N
SmilesCOC1=C(Cl)C2=CC=C(N)C=C2C(=O)O1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO22.56100
ethanol5.6425

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight225.63.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM4.43mL22.16mL44.32mL
5mM0.89mL4.43mL8.86mL
10mM0.44mL2.22mL4.43mL
50mM0.09mL0.44mL0.89mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet