BiologicalActivity
Potent,noncompetitivehumanCCR2antagonist;inhibitsMCP-1-inducedCa2+mobilizationinhCCR2-CHOcells(IC50=13nM).ExhibitsselectivityforCCR2overCCR1,CCR3-8andCXCR1-3.DelaysonsetandreducesneurologicalsignsinanexperimentalautoimmuneencephalomyelitismodelofmultiplesclerosisinhCCR2knock-inmice.Orallyactive.
CompoundLibraries
JNJ27141491isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 379.38 |
| Formula | C17H15F2N3O3S |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 871313-59-6 |
| PubChemID | 11703589 |
| InChIKey | SYARXICKXVXWNA-LBPRGKRZSA-N |
| Smiles | FC1=CC([C@H](CC)N2C(C(OC)=O)=C(C3=CC=NO3)NC2=S)=CC=C1F |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 37.94 | 100 | |
| ethanol | 37.94 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight379.38.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.64mL | 13.18mL | 26.36mL |
| 5mM | 0.53mL | 2.64mL | 5.27mL |
| 10mM | 0.26mL | 1.32mL | 2.64mL |
| 50mM | 0.05mL | 0.26mL | 0.53mL |
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ProductDatasheets
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