BiologicalActivity
PotentandselectiveP2X7antagonist(pIC50valuesare8.3,7.5and7.2forhuman,mouseandratreceptorsrespectively).Selectiveoverapanelof50otherreceptors,ionchannelsandtransporters.ReducesBzATP-inducedIL-1βreleasefrommonocytesinvitroandfromratbraininvivo.Attenuatesamphetamine-inducedhyperactivityinrats.Brainpenetrant.
CompoundLibraries
JNJ47965567isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 488.64 |
| Formula | C28H32N4O2S |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 1428327-31-4 |
| PubChemID | 66553218 |
| InChIKey | XREFXUCWSYMIOG-UHFFFAOYSA-N |
| Smiles | O=C(NCC4(CCOCC4)N3CCN(C5=CC=CC=C5)CC3)C1=CC=CN=C1SC2=CC=CC=C2 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| 1eq.HCl | 24.43 | 50 | |
| DMSO | 48.86 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight488.64.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.05mL | 10.23mL | 20.46mL |
| 5mM | 0.41mL | 2.05mL | 4.09mL |
| 10mM | 0.2mL | 1.02mL | 2.05mL |
| 50mM | 0.04mL | 0.2mL | 0.41mL |
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ProductDatasheets
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