Biological Activity
Selective NPY Y2 antagonist (IC50 = 0.1 μM). Displays 100-fold selectivity over NPY Y1, Y4 and Y5 receptors; also displays selectivity against a panel of 50 receptors, ion channels and transporters. Brain penetrant.
Licensing Information
Sold with the permission of Janssen Pharmaceutica N.V.
Technical Data
| M. Wt | 510.67 |
| Formula | C32H38N4O2 |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 683746-68-1 |
| PubChem ID | 10324083 |
| InChI Key | DSEJCLDJIFTPPH-FMIVXFBMSA-N |
| Smiles | O=C(C)N2CCC1=CC=C(N(C(/C=C/C5=CC=CC(C#N)=C5)=O)C3CCN(CCC4CCCC4)CC3)C=C12 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 5.11 | 10mM with gentle warming | |
| ethanol | 5.11 | 10mM with gentle warming |
Preparing Stock Solutions
The following data is based on the product molecular weight 510.67. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.96 mL | 9.79 mL | 19.58 mL |
| 5 mM | 0.39 mL | 1.96 mL | 3.92 mL |
| 10 mM | 0.2 mL | 0.98 mL | 1.96 mL |
| 50 mM | 0.04 mL | 0.2 mL | 0.39 mL |
Molarity Calculator
Reconstitution Calculator
Dilution Calculator
Product Datasheets
References
References are publications that support the products' biological activity.
Bonaventure et al (2004) Characterization of N-(1-Acetyl-2,3-dihydro-1H-indol-6-yl)-3-(3-cyano-phenyl)-N-[1-(2-cyclopentyl-ethyl)-piperidin-4yl]acrylamide (JNJ-5207787), a small molecule antagonist of the neuropeptide Y Y2 receptor. J.Pharmacol.Exp.Ther. 308 1130 PMID: 14617685
Jablonowski et al (2004) Novel non-peptide neuropeptide Y Y2 receptor antagonists. Bioorg.Med.Chem.Lett. 14 1239 PMID: 14980673
Keywords: JNJ 5207787, supplier, JNJ5207787, neuropeptide, y, NPY, Y2, antagonists, selective, NPY, Receptors, NPY, Receptors, Tocris Bioscience
