Biological Activity
Histamine H4 receptor antagonist; displays high affinity (Ki = 4.5 nM) and is >1000-fold selective for H4 over other histamine receptors.
Licensing Information
Sold with the permission of Ortho-McNeil-Janssen Pharmaceuticals, Inc.
Compound Libraries
JNJ 7777120 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 277.75 |
| Formula | C14H16ClN3O |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 459168-41-3 |
| PubChem ID | 4908365 |
| InChI Key | HUQJRYMLJBBEDO-UHFFFAOYSA-N |
| Smiles | ClC1=CC=C(NC(C(N3CCN(C)CC3)=O)=C2)C2=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1eq. HCl | 27.77 | 100 | |
| DMSO | 13.89 | 50 | |
| ethanol | 13.89 | 50 |
Preparing Stock Solutions
The following data is based on the product molecular weight 277.75. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.6 mL | 18 mL | 36 mL |
| 5 mM | 0.72 mL | 3.6 mL | 7.2 mL |
| 10 mM | 0.36 mL | 1.8 mL | 3.6 mL |
| 50 mM | 0.07 mL | 0.36 mL | 0.72 mL |
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References
References are publications that support the products' biological activity.
Jablanowski et al (2003) The first potent and selective non-imidazole human histamine H4 receptor antagonists. J.Med.Chem. 46 3957 PMID: 12954048
Thurmond et al (2004) A potent and selective histamine H4 receptor antagonist with anti-inflammatory properties. J.Pharmacol.Exp.Ther. 309 404 PMID: 14722321
Strakhova et al (2009) In vitro and in vivo characterization of A-940894: a potent histamine H4 receptor antagonist with anti-inflammatory properties. Br.J.Pharmacol. 157 44 PMID: 19413570
Keywords: JNJ 7777120, supplier, JNJ7777120, histamine, 4, histaminergic, H4, receptors, antagonists, selective, Histamine, H4, Receptors, Histamine, H4, Receptors, Tocris Bioscience
