Biological Activity
DGAT2 inhibitor (IC50 = 140 nM). Exhibits >70-fold selectivity for DGAT2 over DGAT1 and MGAT2.
Technical Data
| M. Wt | 523.38 |
| Formula | C24H16BrFN4O2S |
| Storage | Store at +4°C |
| CAS Number | 1962931-71-0 |
| PubChem ID | 101578741 |
| InChI Key | ZFRHAMOJHTZHLT-LPYMAVHISA-N |
| Smiles | BrC1=C(OC2=C(F)C=C(/C=C3SC(NCCC4=CC=CC=N4)=NC3=O)C=C2)C=CC(C#N)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 52.34 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 523.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.91 mL | 9.55 mL | 19.11 mL |
| 5 mM | 0.38 mL | 1.91 mL | 3.82 mL |
| 10 mM | 0.19 mL | 0.96 mL | 1.91 mL |
| 50 mM | 0.04 mL | 0.19 mL | 0.38 mL |
Molarity Calculator
Reconstitution Calculator
Dilution Calculator
Product Datasheets
References
References are publications that support the products' biological activity.
Qi et al (2012) The use of stable isotope-labeled glycerol and oleic acid to differentiate the hepatic functions of DGAT1 and -2 J.Lipid Res. 53 1106 PMID: 22493088
Irshad et al (2017) Diacylglycerol acyltransferase 2 links glucose utilization to fatty acid oxidation in the brown adipocytes. J.Lipid Res. 58 15 PMID: 27836993
Keywords: JNJ DGAT2-A, supplier, JNJDGAT2-A, Diacylglycerol, O-Acyltransferases, DGAT2, inhibitors, inhibits, DGAT-2iJ, Diacylglycerol, O-Acyltransferase, Diacylglycerol, O-Acyltransferase, Tocris Bioscience
