BiologicalActivity
Cytokinereleaseinhibitor.InhibitsproductionofIL-1β,IL-8,IL-6,IL-10andTNFα(IC50valuesare5.9,7.3,8.8,9.1and11.0nM,respectively)fromLPS-stimulatedPBMCs.Reducesproinflammatorycytokine-releaseandattenuateslungpermeABIlityinaratlunginjurymodel.Inducesapoptosisinleukemiacellsinvitroandprolongssurvivalinamouseleukemiamodel.
CompoundLibraries
JTE607dihydrochlorideisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 597.36 |
| Formula | C25H31Cl2N3O5.2HCl |
| Storage | DesiccateatRT |
| Purity | ≥98%(HPLC) |
| CASNumber | 188791-09-5 |
| PubChemID | 9938544 |
| InChIKey | JUJAUEQJEWIWCQ-FJSYBICCSA-N |
| Smiles | ClC1=C(OCCN2CCN(C)CC2)C(Cl)=CC(C(N[C@@H](CC3=CC=CC=C3)C(OCC)=O)=O)=C1O.Cl.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 59.74 | 100 | |
| water | 59.74 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight597.36.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.67mL | 8.37mL | 16.74mL |
| 5mM | 0.33mL | 1.67mL | 3.35mL |
| 10mM | 0.17mL | 0.84mL | 1.67mL |
| 50mM | 0.03mL | 0.17mL | 0.33mL |
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ProductDatasheets
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