BiologicalActivity
InhibitorofthePARPdomainoftankyrase1and2(TNKS1/2).ActivityresultsinstABIlizationofAxin2andincreaseddegradationofβ-catenin;inhibitstheβ-cateninsignalingpathway.AlsoshowntodecreasecanonicalWntsignalinginSW480andHCT-15coloncarcinomacelllines;reducescellcycleprogressionandproliferationinSW480cellsinvitro.
ExternalPortalInformation
Chemicalprobes.orgisaportalthatoffersindependentguidanceontheselectionand/orapplicationofsmallmoleculesforresearch.TheuseofJW55isreviewedonthechemicalprobeswebsite.
CompoundLibraries
JW55isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 434.48 |
| Formula | C25H26N2O5 |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 664993-53-7 |
| PubChemID | 2946601 |
| InChIKey | ZJZWZIXSGNFWQQ-UHFFFAOYSA-N |
| Smiles | O=C(NCC2(C3=CC=C(OC)C=C3)CCOCC2)C1=CC=C(NC(C4=CC=CO4)=O)C=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 43.45 | 100 | |
| ethanol | 43.45 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight434.48.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.3mL | 11.51mL | 23.02mL |
| 5mM | 0.46mL | 2.3mL | 4.6mL |
| 10mM | 0.23mL | 1.15mL | 2.3mL |
| 50mM | 0.05mL | 0.23mL | 0.46mL |
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