Biological Activity
Potent CB2 selective agonist (Ki = 3.4 nM). Approx. 200-fold selective over CB1 receptors. Active in vivo, reducing spasticity in a murine model of multiple sclerosis. Activity also enhances the release of IL-10 by LPS/IFN-γ-stimulated macrophages and results in downregulation of the IL-12 subunit p40. Also available in water soluble emulsion (Cat. No. 1783).
Technical Data
| M. Wt | 312.49 |
| Formula | C22H32O |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 259869-55-1 |
| PubChem ID | 6918505 |
| InChI Key | YSBFLLZNALVODA-RBUKOAKNSA-N |
| Smiles | [H][C@]([C@]3([H])C(C)(C)O2)(CC(C)=CC3)C1=C2C=C(C(C)(C)CCC)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 15.62 | 50mM with gentle warming | |
| ethanol | 31.25 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 312.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.2 mL | 16 mL | 32 mL |
| 5 mM | 0.64 mL | 3.2 mL | 6.4 mL |
| 10 mM | 0.32 mL | 1.6 mL | 3.2 mL |
| 50 mM | 0.06 mL | 0.32 mL | 0.64 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Baker et al (2000) Cannabinoids control spasticity and tremor in a multiple sclerosis model. Nature 404 84 PMID: 10716447
Correa et al (2005) Activation of cannabinoid CB2 receptor negatively regulates IL-12p40 production in murine macrophages: role of IL-10 and ERK1/2 kinase signaling. Br.J.Pharmacol. 145 441 PMID: 15821753
Huffman et al (1999) 3-(1'-Dimethylbutyl)-1-deoxy-Δ8-THC and related compounds: synthesis of selective ligands for the CB2 receptor. Bioorg.Med.Chem. 7 2905 PMID: 10658595
Pertwee (1999) Pharmacology of cannabinoid receptor ligands. Curr.Med.Chem. 6 635 PMID: 10469884
Keywords: JWH 133, supplier, Potent, selective, CB2, agonists, cannabinoid, receptors, JWH133, cb2r, CB2, Receptors, CB2, Receptors, Tocris Bioscience
