BiologicalActivity
PotentandselectiveMAGLinhibitor.BlockshydrolysisoftheendocannABInoid2-arachidonylglycerol(2-AG)invivointhemousebrain(IC50=8nM).Potentiatesdepolarization-inducedsuppressionofexcitabilityincerebellarPurkinjeneurons.Exhibits>300-foldselectivityforMAGLoverFAAHinvitro.Attenuatesnociceptioninneuropathicandinflammatorypainmodels.Alsoreducesfreefattyacidlevelsinprimarytumors.
LicensingInformation
SoldunderlicensefromTheScrippsResearchInstitute.
CompoundLibraries
JZL184isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 520.49 |
| Formula | C27H24N2O9 |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 1101854-58-3 |
| PubChemID | 25021165 |
| InChIKey | SEGYOKHGGFKMCX-UHFFFAOYSA-N |
| Smiles | O=C(OC6=CC=C([N+]([O-])=O)C=C6)N(CC5)CCC5C(C2=CC=C(OCO3)C3=C2)(O)C1=CC(OCO4)=C4C=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 52.05 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight520.49.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.92mL | 9.61mL | 19.21mL |
| 5mM | 0.38mL | 1.92mL | 3.84mL |
| 10mM | 0.19mL | 0.96mL | 1.92mL |
| 50mM | 0.04mL | 0.19mL | 0.38mL |
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ProductDatasheets
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