BiologicalActivity
PotentandselectiveinhibitoroftypeIbonemorphogenicprotein(BMP)receptors(IC50valuesare1.1,1.8,6.4,34.4,220,302and321nMforALK2,ALK1,ALK6,ALK3,ActRIIA,ALK4andALK5respectively).ReducesBMP4-inducedSmad1/5/8phosphorylationinvitro(IC50=100nM)andinducesdorsalizationofzebrafishembryos.
CompoundLibraries
K02288isalsoofferedaspartoftheTocriscreenPlusandTocriscreenKinaseInhibitorToolboxII.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 352.38 |
| Formula | C20H20N2O4 |
| Storage | Storeat-20°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 1431985-92-0 |
| PubChemID | 46173038 |
| InChIKey | CJLMANFTWLNAKC-UHFFFAOYSA-N |
| Smiles | NC1=NC=C(C3=CC=CC(O)=C3)C=C1C2=CC(OC)=C(OC)C(OC)=C2 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 35.24 | 100 | |
| ethanol | 3.52 | 10mMwithgentlewarming |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight352.38.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.84mL | 14.19mL | 28.38mL |
| 5mM | 0.57mL | 2.84mL | 5.68mL |
| 10mM | 0.28mL | 1.42mL | 2.84mL |
| 50mM | 0.06mL | 0.28mL | 0.57mL |
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ProductDatasheets
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