BiologicalActivity
Potent,selectiveandcompetitiveATMkinaseinhibitor(Ki=2.2nM,IC50valuesare13,2500,9300,16600,>100000and>100000nMatATM,DNA-PK,mTOR,PI3-kinase,PI4-KandATRrespectively).DecreasesviABIlityofMCF-7,A549andHCT116cellsanddecreasesp21CIP1levelsinvitro.ActsasarADIo-andchemosensitizerforthetreatmentofcancer.
CompoundLibraries
KU55933isalsoofferedaspartoftheTocriscreenEpigeneticsToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 395.49 |
| Formula | C21H17NO3S2 |
| Storage | Desiccateat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 587871-26-9 |
| PubChemID | 5278396 |
| InChIKey | XRKYMMUGXMWDAO-UHFFFAOYSA-N |
| Smiles | O=C1C=C(C3=CC=CC4=C3SC5=C(C=CC=C5)S4)OC(N2CCOCC2)=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 39.55 | 100 | |
| ethanol | 19.77 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight395.49.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.53mL | 12.64mL | 25.29mL |
| 5mM | 0.51mL | 2.53mL | 5.06mL |
| 10mM | 0.25mL | 1.26mL | 2.53mL |
| 50mM | 0.05mL | 0.25mL | 0.51mL |
MolarityCalculator
ReconstitutionCalculator
DilutionCalculator
ProductDatasheets
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